Sanger Science – Page 2 – Wellcome Sanger Institute Blog

Mapping the Human Cell Atlas – charting the body’s cellular world

April 8, 2020April 9, 2020 Sanger Institute cancer, COVID-19, Human Cell Atlas, single cell, T-cells min read

The Human Cell Atlas is being used to guide future research into human development, biology, health, and disease.

Sepsis and precision medicine: is it all in your genes?

February 16, 2020March 4, 2020 Sanger Institute gene expression, personalised medicine, precision medicine, sepsis min read

Using gene expression data to stratify patients.

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Genomics in the cloud

February 5, 2020February 6, 2020 Sanger Institute big data, bioinformatics, cancer, data, pan cancer analysis of whole genomes min read

The huge, international Pan-Cancer project is the first large-scale use of distributed cloud computing in genomics. As genomics becomes a big data science, it is likely to be the first of many

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“If you know, there is a Nobel prize for you!” – Searching for the causes of cancer in Czechia

January 5, 2020July 8, 2020 Sanger Institute cancer, mutational signatures, mutographs min read

In a study spanning five continents, researchers are hunting for tell-tale ‘signatures’ left in DNA by the unknown causes of cancer.

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A dangerous new Salmonella strain is emerging in sub-Saharan Africa

October 3, 2019October 3, 2019 Communications Team congo, democratic republic of the congo, drc, drug resistance, drug resistant, ints, invasive non-typhoidal salmonella, Salmonella, salmonella typhimurium, ST313, sub-Saharan Africa min read

Researchers have discovered the first extensively drug resistant non-typhoidal Salmonella in the Democratic Republic of the Congo

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The biology of the brain

September 25, 2019September 25, 2019 Communications Team brain, mice, mouse, neurobiology, neurodevelopmental, psychiatric, rare genetic conditions min read

Studying mouse brain development can give insights into human neurodevelopmental and psychiatric disorders, as well as help diagnose rare genetic conditions

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Health implications of the baby biome?

September 18, 2019October 15, 2019 Communications Team antibiotics, babies, bacteria, birth, c-section, caesearean section, gut microbiome, micriobiota, microbiome min read

The method of a baby’s birth affects its collection of gut microbes – its microbiome. But we still don’t know if that has any long-term effects on health

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Powering discovery in blood disorders and depression

September 11, 2019September 11, 2019 Communications Team blood, blood cells, data, data sets, depression, dna sequencing, human genetics programme, uk biobank, whole genomes min read

The wealth of information available to researchers through UK Biobank is powering studies into human health and disease

Malaria Cell Atlas research. Image credit: Petra Korlevic

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Malaria Cell Atlas: mapping a murderous parasite’s life cycle

August 22, 2019August 22, 2019 MarkThomson MarkThomson malaria, malaria cell atlas, mca, parasites and microbes, Plasmodium, single cell min read

Malaria – and the parasite that causes it – is complicated. Not only does the single-celled parasite move between humans and mosquitoes, but it exists in different forms, each with different shapes and functions. Researchers have now mapped out its life cycle in more detail than ever before.

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The modern rise of an ancient disease

August 8, 2019November 5, 2020 Communications Team bacteria, drug resistance, macrolides, sexually transmitted disease, std, syphilis, treponema pallidum, yaws min read

Sanger scientists have sequenced the largest number of Treponema pallidum bacterial genomes to date. The bacterium causes syphilis, a sexually transmitted disease that is making a comeback. Their findings show us how the bacteria have evolved over time and developed resistance to antibiotics.