What are somatic mutations?

2026-01-15T11:52:25+00:0015 January 2026|

When most people think about genetic changes, or mutations, they imagine inherited conditions that are passed on from parents to offspring. However, the vast majority of mutations in our DNA are not inherited at all. Instead, they arise quietly, cell-by-cell throughout our lifetime. These are somatic mutations, and they are one of the most important – yet least understood – forces acting inside our bodies.

Understanding respiratory viruses in the age of the ‘super flu’

2025-12-23T12:19:23+00:0023 December 2025|

For many, flu season has come earlier this year with hospitalisations rising by more than 50 per cent in one week in the UK. The so-called ‘super flu’ is causing a media frenzy – but what actually is it? Why are we seeing it earlier than usual? And how can we be better prepared in the future?

Five questions on butterfly and moth genomics with Charlotte Wright

2025-12-12T16:02:08+00:0011 December 2025|

Drawn to genomics like a moth to a flame, Wellcome Sanger Institute Postdoctoral Fellow, Dr Charlotte Wright, shares with us how she uses genomics to shed light on the evolutionary history of butterflies and moths, and how they might change in the future.

Why bacterial carriage matters for antimicrobial resistance

2025-12-01T16:07:58+00:002 December 2025|

The CARRIAGE study reveals critical insights into the role of Staphylococcus aureus in antimicrobial resistance (AMR). We caught up with Dr Ewan Harrison to discuss how the CARRIAGE study impacts our understanding of how to tackle AMR.

How can we avoid cancer?

2025-11-28T15:34:02+00:0028 November 2025|

Imagine if our bodies held secret playbooks for stopping cancer before it ever gains ground. A new international research team – led by scientists at the Wellcome Sanger Institute – is setting out to uncover exactly those natural defence mechanisms. Their ambitious Cancer Avoidance project hopes to reveal insights that could one day help us halt cancer in its tracks.

What is spatial transcriptomics?

2025-10-22T00:08:42+01:0022 October 2025|

Ever wondered what your cells are up to in their own neighbourhoods? Spatial transcriptomics is opening a new frontier where space meets gene expression, revealing hidden insights into how tissues function, interact and change in health and disease.

“I’m not trying to do science just for scientists. I’m doing it to try to solve important problems that will make a difference”: Jussi Taipale on genomics at scale and predicting gene expression

2025-10-15T09:34:15+01:0016 October 2025|

Professor Jussi Taipale joined the Wellcome Sanger Institute in January this year as a Senior Group Leader in the Generative and Synthetic Genomics Programme. His ambition? To predict gene expression directly from DNA sequence. In this blog, he reflects on his international research journey, how biology is scaling up, and why his research group aims to solve one of the biggest puzzles in genomics.