Dr Kamil Jaron is interested in strange reproduction (in a genomic sense). His work is exploring the changes in DNA variation and chromosome structure caused by the different ways species reproduce, to see how this drives evolution.
The world’s largest human genome sequencing project has been for UK Biobank – a large-scale biomedical database. Sanger staff have sequenced 243,633 human genomes in 3.5 years.
In 2019, the Sanger Institute started on the most ambitious human genome sequencing project in the world. Three years later, the Institute has delivered nearly 250,000 whole human genome sequences and over 20 petabytes (PB) of data, for the UK Biobank project, to aid research into health and disease.
Decade-long surveillance of a deadly bacterial pathogen has shown how genomics can be used to design effective vaccines and combat antimicrobial resistance.
A decades-long interest in cell surface proteins has led to discoveries as diverse as how malaria parasites invade human blood cells, a vaccine target for a neglected tropical disease, and finding the molecules that must interact to initiate new life.
Dr Josie Bryant is a new group leader at the Sanger Institute. She is interested in how microbes in the human lung evolve and adapt over time and how this affects health and disease. We spoke to Josie about the inspirations behind her science, returning to Sanger, and what excites her about establishing a new research group.