Wellcome Sanger Institute Blog

New computational method reveals where genes are expressed

06.04.18 Valentine Svensson explains how the new computational method SpacialDE interprets single-cell data to identify which genes are switched on in different locations, allowing researchers to zoom into the structures of tissues. Continue reading →

Sequencing a superbug: How typhoid became extensively drug-resistant

20.02.18 Gordon Dougan and Elizabeth Klemm report how their laboratory has been sequencing the DNA of Salmonella Typhi strains that infect people around the world, and we have found evidence for an accelerating evolution of resistance to antibiotics Continue reading →

Big data for mosquito control

20.12.17 Alistair Miles explains how the Anopheles gambiae 1000 Genomes project is helping to understand the evolution and spread of insecticide resistance in mosquitos across Africa, supporting the campaign to eliminate malaria.

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Life in the fast lane: rapid reproduction in malaria parasites

1.12.17 Brandon Invergo investigates how quickly malaria parasites can prepare to sexually reproduce once they are picked up by a mosquito. Continue reading →

Alzheimer’s Disease: The puzzle we’re so desperate to solve

13.11.17 Fiona Calvert is using stem cells to study Alzheimer’s Disease. Read her shortlisted article for the Max Perutz Science Writing Competition about this work. Continue reading →

A step towards an effective, multi-target vaccine for malaria

Gareth Powell and Leyla Bustamante helped to find five targets on the parasite that could be the basis of a new vaccine Continue reading →

Results of the Chordoma Genome Project reveal genetic changes that drive chordoma

DATE: 12/09/17 By: Chordoma Foundation Team Editor’s Note: This blog is reproduced from The Chordoma Foundation blog, a charity that has funded and collaborated on recent research by Sanger Institute scientists. For more on The Chordoma Foundation, please visit: https://www.chordomafoundation.org/ This month, a group of chordoma scientists led by Dr. Adrienne Flanagan of University College London (UCL), Dr … Continue reading →

Editing embryos – Could you? Would you? Should you? Views from Genetic Counsellors

03.08.17 This week the American Society of Human Genetics issued a policy on the application of germline editing – the ability to alter the genetic makeup of early stage embryos. Anna Middleton, one of the contributors to the statement, explains the policy’s position Continue reading →

Placing drug-resistant strains of E. coli into a broader context

18.7.17 Samples of E. coli were isolated from patients with bloodstream infections over eleven years. Teemu Kallonen, Julian Parkhill and Sharon Peacock discuss what their genomic study on this collection reveals.
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