Sanger Science

1 September 2026
5 questions on CRISPR-Cas with Sandeep Rajan
From bacterial defence to breakthrough therapies, we explore how CRISPR-Cas is transforming research and healthcare, and how experts at the Wellcome Sanger Institute are refining the technology to make genome editing more scalable and effective.

25 August 202612.4 min read
One gene, many outcomes: Understanding variable cancer risk in PTEN hamartoma tumour syndrome
Changes in the PTEN gene, that causes PTEN hamartoma tumour syndrome (PHTS), can lead to a range of different manifestations that vary from person to person, including an increased risk of certain cancers. A new project aims to understand why some tissues in people with PHTS become cancerous, and if there is a way of identifying individuals with PTEN variants who are most at risk.

11 November 202512.9 min read
Five questions on genomics in Latin America with Dr Patricia Abrão Possik
Despite its extraordinary genetic diversity, Latin America remains largely absent from global genomic studies. Dr Patricia Abrão Possik discusses efforts to boost regional research capacity and insights from her work on acral melanoma.
22 October 20259 min read
What is spatial transcriptomics?
Ever wondered what your cells are up to in their own neighbourhoods? Spatial transcriptomics is opening a new frontier where space meets gene expression, revealing hidden insights into how tissues function, interact and change in health and disease.
16 October 20258.9 min read
“I’m not trying to do science just for scientists. I’m doing it to try to solve important problems that will make a difference”: Jussi Taipale on genomics at scale and predicting gene expression
Professor Jussi Taipale joined the Wellcome Sanger Institute in January this year as a Senior Group Leader in the Generative and Synthetic Genomics Programme. His ambition? To predict gene expression directly from DNA sequence. In this blog, he reflects on his international research journey, how biology is scaling up, and why his research group aims to solve one of the biggest puzzles in genomics.
7 October 20257 min read
Five questions on lupus with Catherine Sutherland
In recognition of UK Lupus Awareness Month, we caught up with Catherine Sutherland, Computational Senior Staff Scientist in the Human Genetics programme at the Wellcome Sanger Institute, to discuss more about how their work is contributing to our understanding of lupus.
1 October 202530.2 min read
Ten ways the Sanger Institute is tackling the global fight against AMR
Our scientists and collaborators are working together to tackle one of the biggest public health threats: antimicrobial resistance. We are using cutting-edge genomics to hunt down drug-resistant microbes, decode their secrets and stop them in their tracks.
9 September 202510.2 min read
Five ways Health and Safety are enabling our science
Health and safety can often be seen as all red pen and tape but it is not what you think. Our team at the Wellcome Sanger Institute are providing advice and guidance to help enable our projects and keep everyone in one piece.