Month: September 2012

A Cornucopia of Candidates for Deafness

25 Sept 2012: Morag Lewis talks about a review she has had published in Cell. The study looked at genes and investigated how the loss of those genes affected the fly. Losing some of the genes resulted in a totally deaf fly, while others affected just some aspects of the fly’s hearing.

Chipping away at the genetics of PBC

21 Sept 2012: Jimmy Liu disscusses his recent research discovering and refining genetic regions linked to susceptibility for primary biliary cirrhosis, or PBC, an immune-mediated disease that causes the progressive destruction of liver bile ducts.

Sanger paper is 2011 best of Journal of Biological Chemistry

19 Sept 2012: A team from the Wellcome Trust Sanger Institute have identified a seventh, unusual proteolytic enzyme in an asparagine catalytic type. This study has been picked as one of 20 best papers published by the Journal of Biological Chemistry in 2011, out of a total of 4,000 papers.

Is it as plain as the nose on one’s face?

13 Sept 2012: Have you ever considered whether we all sense the world the same way? Darren Logan at the Sanger Institute studies how our genes influence how we perceive the environment around us, and how our brains makes sense of our senses.

Walking a thousand miles starts with one step

11 Sept 2012: The Malaria Programme at the Wellcome Trust Sanger Institute is carrying out research addressing questions about the continuing emergence of drug resistance in malaria. Knowing which proteins in a cell are palmitoylated, specific protein-membrane interactions, can give important clues about their regulation or function—clues that can be used to piece together new ideas about how cells work.

Muscle cells’ social etiquette: are they aloof, friendly or just good talkers?

7 Sept 2012: In the embryo, muscle cells grow and knit together to eventually make up the size and shape of every muscle in the adult body. How do they do this? The answer is vital for treating muscular disease, because discovering how muscle is made will help to us understand how to fix the molecular machinery in muscles that don’t work.

Laboratory Mouse

Handle with care: animal husbandry’s virtuous circle

3 Sept 2012: Jacqui White, from the Institute’s Mouse Genetics team, describes how our researchers are committed to treating their animals in the most humane, caring and sensitive way possible …